INA Rabbit anti-Human, Polyclonal, Bethyl Laboratories

Catalog No.	Quantity
50-157-0409	10 μL

Catalog No. 50-157-0409 Supplier Bethyl Laboratories, Inc Supplier No. A305431AT

Description

Rabbit Polyclonal Antibody

The recommended shelf life for this product is 1 year from date of receipt. Based on 100% sequence identity, this antibody is predicted to react with Mouse, Rat and Bovine

Alpha internexin is a Class IV intermediate filament originally discovered as it copurifies with other neurofilament subunits. On SDS-PAGE gels it runs with an apparent molecular weight of 64 to 66 kDa, with some species variability, although the real molecular weight is about 55kDa; as with the other neurofilament subunits the presence of highly negatively charged sequences results in reduction of SDS-PAGE mobility. a-internexin is related to but distinct from the better known neurofilament triplet proteins, NF-L, NF-M and NF-H, having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development, but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain a-internexin in addition to NF-L, NF-M and NF-H. In some mature neurons a-internexin is the only neurofilament subunit expressed. Antibodies to a-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition, the very early developmental expression of a-internexin means its presence is an early and convenient diagnostic feature of neuronal progenitors cells and other cells committed to the neuronal lineage. In addition, recent studies show a marked up-regulation of a-internexin during neuronal regeneration.

Specifications

• Antigen: INA
• Applications: Immunoprecipitation
• Classification: Polyclonal
• Concentration: 1 mg/ml
• Conjugate: Unconjugated
• Formulation: phosphate, tris citrate with 0.09% sodium azide; pH 7-8
• Gene: INA
• Gene Accession No.: Q16352
• Gene Alias: 66 kDa neurofilament protein, Internexin neuronal intermediate filament protein alpha, MGC12702, NEF5, Neurofilament 5 (66kD), Neurofilament 66, Neuro
• Gene Symbols: INA
• Host Species: Rabbit
• Immunogen: Between 300 and 350
• Purification Method: Antigen affinity chromatography
• Quantity: 10 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 9118
• Target Species: Human
• Content And Storage: 4° C
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG