Inhibitor of calcineurin-substrate association
Manufacturer: Tocris 2162/50
DescriptionInhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
- Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
- Formula: C20H12O2
- CAS Number: 3519-82-2
- Solubility: Soluble to 20mM in DMSO
- Purity: >98