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  5. Tocris Bioscience™ Indisulam

Tocris Bioscience™ Indisulam
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Catalog No. 67825
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Quantity:
5 mg
25 mg
This item is not returnable. View return policy
This item is not returnable. View return policy

Description

Molecular glue; pre-mRNA splicing modulator

Indisulam is an acts as a molecular glue to induce proteosomal degradation of mRNA splicing factor RBM39 (also designated CAPERα, HCC1, FSAP59, and RNPC2), via binding to DCAF15. Acts as a pre-mRNA splicing modulator (SPLAMs; splicing inhibitor sulfonamides), causes aberrant pre-mRNA splicing. Suppresses proliferation of cancer cell lines. Reduces viability of HCT-116 cells (IC50 = 0.56 μM). Induces cell cycle arrest in the G1 phase in cancer cell lines. Also a high affinity carbonic anhydrase isozyme XII (hCA XII) inhibitor (Ki = 3.0-5.7 nM).

Specifications

Chemical Name or Material N1-(3-Chloro-1 H-indol-7-yl)-1,4-benzenedisulfonamide
CAS 165668-41-7
Quantity 5 mg
Target Ubiquitin Ligase (E3) Inhibitors
Molecular Formula C14H12ClN3O4S2
Formula Weight 385.84
Product Type pre-mRNA Splicing Modulator
Purity 98%
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