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Tocris Bioscience™ INDY Available on GSA/VA Contract for Federal Government customers only.

DYRK1A/B inhibitor

Manufacturer:  Tocris Bioscience™ 4997/10

Catalog No. 49-971-0R


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Description

Description

DYRK1A/B inhibitor (IC50 values are 0.23 and 0.24 μM, for DYRK1B and DYRKA respectively). Binds at the ATP-binding cleft of the enzyme. Reverses aberrant tau-phosphorylation and rescues repressed calcineurin/NFAT signaling. Impairs the self-renewal capacity of subventricular zone neural stem cells. Also available as a prodrug, proINDY (Cat. No. 4998).

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