Invitrogen™ Influenza A H1N1 M1 (A/Puerto Rico/8/34/Mount Sinai) Monoclonal Antibody (02)

Catalog No.	Quantity
PIMA529938	100 μL

Catalog No. PIMA529938 Supplier Invitrogen™ Supplier No. MA529938

Description

Mouse Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). This antibody has specificity for H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1/Matrix Protein 1.

Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.

Specifications

• Antigen: Influenza A H1N1 M1 (A/Puerto Rico/8/34/Mount Sinai)
• Applications: ELISA
• Classification: Monoclonal
• Clone: 02
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with no preservative
• Gene Alias: H1N1 M
• Host Species: Mouse
• Immunogen: Recombinant H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 protein.
• Purification Method: Protein A
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Target Species: Virus
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1