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Invitrogen™ Influenza A H1N1 M1 (A/Puerto Rico/8/34/Mount Sinai) Recombinant Rabbit Monoclonal Antibody (111)
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Catalog No. PIMA529939
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100 μL
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PIMA529939 100 μL
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Catalog No. PIMA529939 Supplier Invitrogen™ Supplier No. MA529939
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Description

Rabbit Recombinant Monoclonal Antibody

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems. The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits. Then, individual clones are screened to select the best candidates for production. The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire. This antibody has specificity for H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1.

Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Influenza A H1N1 M1 (A/Puerto Rico/8/34/Mount Sinai)
Applications ELISA
Classification Recombinant Monoclonal
Clone 111
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene Alias H1N1 M
Host Species Rabbit
Immunogen Recombinant H1N1 (A/Puerto Rico/8/34/Mount Sinai) M1 protein.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Target Species Virus
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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