Invitrogen™ Influenza H5N1 HA Recombinant Human Monoclonal Antibody (H011)

Human Recombinant Monoclonal Antibody

Supplier:  Invitrogen™ MA529949

Catalog No. PIMA529949

Description

This product is preservative free. It is recommended to add sodium azide to avoid contamination (final concentration 0.05%-0.1%). Recombinant antibodies are produced using specific genes that code for the desired antibodies. These genes are cloned into an expression vector and expressed in vitro. The advantages of recombinant antibodies include: better specificity, animal origin-free formulation, and more lot-to-lot consistency. This antibody has specificity for H5N1 (A/Hubei/1/2010) HA H5N1 (A/Xinjiang/1/2006) HA1 H5N1 (A/Xinjiang/1/2006) HA H5N1 (A/bar-headed goose/Qinghai/1A/2005) HA H5N1 (A/Anhui/1/2005) HA H5N1 (A/Cambodia/S1211394/2008) HA H5N1 (A/Duck/Hong Kong/p46/97) HA H5N1 (A/Hong kong/213/2003) HA (28 Ser/Trp) H5N1 (A/chicken/India/NIV33487/06) HA H5N1 (A/Cambodia/R0405050/2007) HA H5N1 (A/whooper swan/Mongolia/244/2005) HA H5N1 (A/Egypt/N05056/2009) HA H5N1 (A/Common magpie/Hong Kong/2256/2006) HA H5N1 (A/duck/Hunan/795/2002) HA H5N1 (A/Egy.

Influenza A virus is a major public health threat, killing more than 30,000 people per year in the USA. In early 2009, a novel swine-origin influenza A (H1N1) virus was identified in specimens obtained from patients in Mexico and the United States. The virus spread quickly around the world and on June 11, 2009, the World Health Organization declared it a pandemic. Influenza A virus has one of sixteen possible Hemagglutinin (HA) surface proteins and one of nine possible Neuraminidase (NA) surface proteins. The Hemagglutinin protein facilitates viral attachment while Neuraminidase is involved in viral release. These proteins also elicit immune responses that prevent infection or independently reduce viral replication. The genetic make-up of this swine flu virus is unlike any other: it is an H1N1 strain that combines a triple assortment first identified in 1998 including human, swine, and avian influenza with two new pig H3N2 virus genes from Eurasia, themselves of recent human origin. The distinct antigenic properties of the new swine influenza virus compared with seasonal influenza A (H1N1) virus suggest that human immunity against new swine influenza virus is limited, although the age distribution of reported cases suggests some degree of protection in older age groups.

Specifications

• Antigen: Influenza H5N1 HA
• Classification: Recombinant Monoclonal
• Concentration: 4.09 mg/mL
• Formulation: arginine, Histidine with 120mM NaCl, 0.02% Tween 80 and no preservative; pH 6
• Host Species: Human
• Purification Method: SDS-PAGE
• Regulatory Status: RUO
• Target Species: Virus
• Product Type: Antibody
• Isotype: IgG1

• Applications: Inhibition Assays, Neutralization
• Clone: H011
• Conjugate: Unconjugated
• Gene Alias: flu hemagglutinin; influenza hemagglutinin
• Immunogen: Influenza H5N1 Hemagglutinin/HA protein.
• Quantity: 200 μg
• Primary or Secondary: Primary
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid