Invitrogen™ ING3 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA540702

Catalog No. PIPA540702

Description

Peptide sequence: MDQLEQRVSE FFMNAKKNKP EWREEQMASI KKDYYKALED ADEKVQLANQ Sequence homology: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Zebrafish: 100%.

The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.

Specifications

• Antigen: ING3
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: ING3
• Gene Alias: 1300013A07Rik; Eaf 4; Eaf4; FLJ20089; HSPC301; ING 2; ING 3; ING2; ING3; ing3 protein; inhibitor of growth family member 3; inhibitor of growth family, member 3; inhibitor of growth protein 3; inhibitor of growth protein 3-like protein; MEAF4; p47 p47 ING3; p47 regulator protein; p47ING3; p47ING3 protein; zgc:56327
• Host Species: Rabbit
• Purification Method: Affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 54556
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: Western Blot
• Concentration: 0.5 mg/mL
• Formulation: PBS with 2% sucrose and 0.09% sodium azide
• Gene Accession No.: Q9NXR8
• Gene Symbols: ING3
• Immunogen: Synthetic peptide directed towards the N-terminal of human ING3 (aa 36-85).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov