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ING4 Polyclonal Antibody, Invitrogen™

Catalog No. PIPA5100901
Encompass
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PIPA5100901 100 μL
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Catalog No. PIPA5100901 Supplier Thermo Scientific Supplier No. PA5100901

Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total ING4.

The ING4 gene belongs to the ING (Inhibitor of Growth) family of tumor suppressors. All five members of the ING protein family identified to date contain a highly conserved plant homeodomain (PHD) finger motif at the C-terminal end, which is found in transcription factors that modulate chromatin structure. ING proteins have been shown to form transcriptional complexes leading to activation of responsive genes that mediate a wide range of cellular functions, including growth arrest, DNA repair, gene transcription, apoptosis, and senescence. The candidate tumor suppressor ING4 has a role in brain tumor pathogenesis, and is involved in regulating tumor growth and angiogenesis. Expression of ING4 is reduced in gliomas compared to normal brain tissue, and ING4 reduction correlates with progression from lower to higher grades of tumors. ING4 physically interacts with the p65 (RelA) subunit of NF-kB and represses transcription of NF-kB responsive genes. Inactivating mutations in ING4 transcripts have been described in various human cancer cell lines, and deletion of the ING4 locus has been detected in 10-20% of human breast cancer cell lines and tumors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen ING4
Applications Immunocytochemistry, Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene ING4
Gene Accession No. Q8C0D7, Q9UNL4
Gene Alias brain my036 protein; candidate tumor suppressor p33 ING1 homolog; D6Wsu147e; D6Xrf92; ING1-like protein; Ing4; inhibitor of growth family member 4; inhibitor of growth family, member 4; inhibitor of growth protein 4; My036; p29ING4
Gene Symbols ING4
Host Species Rabbit
Immunogen A synthesized peptide derived from human ING4(Accession Q9UNL4), corresponding to amino acid residues S123-M173.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 28019, 297597, 51147
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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