MilliporeSigma™ INK4b (p15), Mouse, Unlabeled, Clone: GF10 (10C7A6),

Catalog No.	Quantity	Conjugate
MABE1664MI	100 μL	Unconjugated

Catalog No. MABE1664MI Supplier MilliporeSigma™ Supplier No. MABE1664

Description

Mouse Monoclonal Antibody

Cyclin-dependent kinase 4 inhibitor B (UniProt P42772; also known as MTS-2, Multiple tumor suppressor 2, p14-INK4b, p15-INK4b, p15INK4B) is encoded by the CDKN2B (also known as MTS2) gene (Gene ID 1030) in human. The INK and CIP/KIP families of cyclin dependent kinase inhibitors (CDKis) protect cells from oncogenic signals-initiated cellular transformation. INK4a and INK4b (encoded by the CDKN2A and CDKN2B gene, respectively) constitute the INK4 subfamily of CDKis. INK4a and INK4b are induced by oncogenic Ras and are involved in cell cycle G1 arrest and cellular senescence. Inactivation of CDKN2A and CDKN2B are found in a wide variety of human malignancies and murine tumor models.

Specifications

• Antigen: INK4b (p15)
• Applications: Western Blot
• Classification: Monoclonal
• Clone: GF10 (10C7A6)
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Mouse monoclonal IgG1κ hybridoma culture supernatant with 0.05% Sodium Azide.
• Gene: CDKN2B, MTS2
• Gene Accession No.: P42772
• Host Species: Mouse
• Immunogen: Recombinant full-length human INK4b (p15).
• Purification Method: Unpurified
• Quantity: 100 μL
• Regulatory Status: RUO
• Research Discipline: Epigenetics & Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_004927
• Test Specificity: Clone GF10 (10C7A6), Mfr. No. MABE1664 and clone GF7 (7CIG4), Mfr. No. 05-430 correspond to two independent clones originated from the same mouse host. Clone GF10 (10C7A6) is recommended as an alternative to clone GF7 (7CIG4), however these two clones are expected to recognize different epitopes, exhibit different target-binding affinity and species cross-reactivity. Cross-reactivity of clone GF10 (10C7A6) toward spliced isoform 2 (p10; UniProt P42772-2) has not been confirmed.
• Target Species: Human
• Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
• Form: Culture Supernatant
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.