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Invitrogen™ INPP5E Polyclonal Antibody
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Catalog No. PIPA564248
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100 μL
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PIPA564248 100 μL
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Catalog No. PIPA564248 Supplier Invitrogen™ Supplier No. PA564248
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GKDTYDSTSK QRTPSYTDRV LYRSRHKGDI CPVSYSSCPG IKTSDHRPVY GLFRVKVRPG RDNIPLAAGK FDRELYLLGI KRRISKEIQR QQALQSQNSS TICSVS Highest antigen sequence identity to the following orthologs: Mouse - 90%, Rat - 91%.

INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INPP5E
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Inpp5e
Gene Accession No. Q9NRR6
Gene Alias 1200002L24Rik; 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; 72kDa; CORS1; CPD4; inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase E; inositol polyphosphate-5-phosphatase, 72 kDa; INPP5E; JBTS1; mKIAA0123; MORMS; Pharbin; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PPI5PIV
Gene Symbols Inpp5e
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human INPP5E. Recombinant protein control fragment (Product #RP-103817).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 56623
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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WARNING: Cancer - www.P65Warnings.ca.gov
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