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Invitrogen™ INPP5E Polyclonal Antibody
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Catalog No. PIPA5103551
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PIPA5103551 100 μL
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Catalog No. PIPA5103551 Supplier Invitrogen™ Supplier No. PA5103551
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total INPP5E.

INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.
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Specifications

Antigen INPP5E
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Inpp5e
Gene Accession No. Q9JII1, Q9NRR6, Q9WVR1
Gene Alias 1200002L24Rik; 5-phosphatase that induces arborization; 72 kDa inositol polyphosphate 5-phosphatase; 72kDa; CORS1; CPD4; inositol polyphosphate 5-phosphatase; inositol polyphosphate-5-phosphatase E; inositol polyphosphate-5-phosphatase, 72 kDa; INPP5E; JBTS1; mKIAA0123; MORMS; Pharbin; phosphatidylinositol 4,5-bisphosphate 5-phosphatase; Phosphatidylinositol polyphosphate 5-phosphatase type IV; Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase; phosphatidylinositol-4,5-bisphosphate 5-phosphatase; PPI5PIV
Gene Symbols Inpp5e
Host Species Rabbit
Immunogen A synthesized peptide derived from human INPP5E(Accession Q9NRR6), corresponding to amino acid residues G522-S572.
Purification Method Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114089, 56623, 64436
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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