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INPP5E Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
SDP

Catalog No. 50555268 Shop All Proteintech Group Inc Products
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50-555-268 150 μL
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Catalog No. 50-555-268 Supplier Proteintech Group Inc Supplier No. 177971AP150UL
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Description

Rabbit Polyclonal Antibody

INPP5E (inositol polyphosphate 5-phosphatase), also known as phosphatidylinositol polyphosphate 5-phosphatase type IV, is a 644 amino acid peripheral membrane protein associated with Golgi stacks. Belonging to the inositol-1, 4, 5-trisphosphate 5-phosphatase type IV family, INPP5E converts phosphatidylinositol-3, 4, 5-triphosphate (PtdIns 3, 4, 5-P3) to PtdIns-P2. While inactive towards water soluble inositol phosphates, the activity of INPP5E is specific for lipid substrates. INPP5E becomes phosphorylated upon DNA damage and is expressed in brain, heart, pancreas, testis and spleen. Defects in INPP5E are the cause of Joubert syndrome type 1 (JBTS1), a disorder presenting with cerebellar ataxia, oculomotor apraxia, hypotonia, neonatal breathing abnormalities and psychomotor delay. In addition, mutations in the INPP5E gene may lead to mental retardation-truncal obesity-retinal dystrophy-micropenis (MORMS), an autosomal recessive disorder characterized by moderate mental retardation, truncal obesity, congenital non-progressive retinal dystrophy, and micropenis in males.

Specifications

Antigen INPP5E
Applications Immunocytochemistry, Immunofluorescence, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Polyclonal
Concentration 0.36 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene INPP5E
Gene Accession No. Q9JII1, Q9NRR6, Q9WVR1
Gene Alias INPP5E, PPI5PIV
Gene Symbols INPP5E
Host Species Rabbit
Immunogen INPP5E Fusion Protein Ag11959
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 114089, 56623, 64436
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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