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Invitrogen™ INSIG1 Polyclonal Antibody
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Catalog No. PIPA5100150
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PIPA5100150 100 μL
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Catalog No. PIPA5100150 Supplier Invitrogen™ Supplier No. PA5100150
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total INSIG1.

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INSIG1
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene INSIG1
Gene Accession No. O15503, Q8BGI3
Gene Alias 1810013C12Rik; CL6; CL-6; fb55a03; fi35b10; growth response protein (CL-6); immediate-early protein CL-6; INSIG1; INSIG-1; INSIG-1 membrane protein; insulin induced gene 1; insulin induced protein 1; insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405; wu:fb55a03; wu:fi35b10; zgc:55439
Gene Symbols INSIG1
Host Species Rabbit
Immunogen A synthesized peptide derived from human INSIG1(Accession O15503), corresponding to amino acid residues W127-A177.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 231070, 3638
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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