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Invitrogen™ INSIG1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA116988

Catalog No. 01-670-141


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Description

Description

This antibody does not cross-react with Insig2. Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY
Specifications

Specifications

INSIG1
Polyclonal
Unconjugated
INSIG1
1810013C12Rik; CL6; CL-6; fb55a03; fi35b10; growth response protein (CL-6); immediate-early protein CL-6; INSIG1; INSIG-1; INSIG-1 membrane protein; insulin induced gene 1; insulin induced protein 1; insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405; wu:fb55a03; wu:fi35b10; zgc:55439
Rabbit
Antigen affinity chromatography
RUO
3638, 64194
-20°C, Avoid Freeze/Thaw Cycles
Liquid
Western Blot, Immunocytochemistry
1.02 mg/mL
PBS with 30% glycerol and 0.1% sodium azide
O15503, Q08755
INSIG1
Synthetic peptide corresponding to a region between residues 1-100 of human Insig1.
100 μL
Primary
Human, Rat
Antibody
IgG
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