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Invitrogen™ INSIG1 Polyclonal Antibody
Rabbit Polyclonal Antibody
Supplier: Invitrogen™ PA116988
Description
This antibody does not cross-react with Insig2. Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).
Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Specifications
INSIG1 | |
Polyclonal | |
Unconjugated | |
INSIG1 | |
1810013C12Rik; CL6; CL-6; fb55a03; fi35b10; growth response protein (CL-6); immediate-early protein CL-6; INSIG1; INSIG-1; INSIG-1 membrane protein; insulin induced gene 1; insulin induced protein 1; insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405; wu:fb55a03; wu:fi35b10; zgc:55439 | |
Rabbit | |
Antigen affinity chromatography | |
RUO | |
3638, 64194 | |
-20°C, Avoid Freeze/Thaw Cycles | |
Liquid |
Western Blot, Immunocytochemistry | |
1.02 mg/mL | |
PBS with 30% glycerol and 0.1% sodium azide | |
O15503, Q08755 | |
INSIG1 | |
Synthetic peptide corresponding to a region between residues 1-100 of human Insig1. | |
100 μL | |
Primary | |
Human, Rat | |
Antibody | |
IgG |
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