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Invitrogen™ INSIG1 Polyclonal Antibody
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Catalog No. 01670141
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100 μL
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Catalog No. Quantity
01-670-141 100 μL
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Catalog No. 01-670-141 Supplier Invitrogen™ Supplier No. PA116988
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Description

Rabbit Polyclonal Antibody

This antibody does not cross-react with Insig2. Suggested positive control: HepG2 lysate, antigen standard for INSIG1 (transient overexpression lysate).

Oxysterols regulate cholesterol homeostasis through liver X receptor (LXR) and sterol regulatory element-binding protein (SREBP) mediated signaling pathway. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INSIG1
Applications Western Blot, Immunocytochemistry
Classification Polyclonal
Concentration 1.02 mg/mL
Conjugate Unconjugated
Formulation PBS with 30% glycerol and 0.1% sodium azide
Gene INSIG1
Gene Accession No. O15503, Q08755
Gene Alias 1810013C12Rik; CL6; CL-6; fb55a03; fi35b10; growth response protein (CL-6); immediate-early protein CL-6; INSIG1; INSIG-1; INSIG-1 membrane protein; insulin induced gene 1; insulin induced protein 1; insulin-induced gene 1 protein; Insulin-induced growth response protein CL-6; MGC1405; wu:fb55a03; wu:fi35b10; zgc:55439
Gene Symbols INSIG1
Host Species Rabbit
Immunogen A synthetic peptide representing an internal region of the human INSIG-1 protein (between residues 1-100).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3638, 64194
Target Species Human, Rat
Content And Storage -20°C, Avoid Freeze/Thaw Cycles
Product Type Antibody
Form Liquid
Isotype IgG
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