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INSR alpha Monoclonal Antibody (47-9), Invitrogen™

Catalog No. PIMA513773
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500 μL
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PIMA513773 500 μL
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Catalog No. PIMA513773 Supplier Thermo Scientific Supplier No. MA513773
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Description

Mouse Monoclonal Antibody

MA5-13773 targets Insulin Receptor alpha in IA applications and shows reactivity with Bovine, Human, Ovine, and Porcine samples. The MA5-13773 immunogen is iM-9 lymphocytes followed by purified insulin receptor.

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INSR alpha
Applications Inhibition Assays
Classification Monoclonal
Clone 47-9
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene INSR
Gene Accession No. P06213
Gene Alias 4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B
Gene Symbols INSR
Host Species Mouse
Immunogen IM-9 lymphocytes followed by purified insulin receptor
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3643, 396755, 408017, 443431
Target Species Bovine, Human, Ovine, Pig
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1
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