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Invitrogen™ INSR alpha Recombinant Mouse Monoclonal Antibody (83-7)
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Catalog No. PIMA547792
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200 μg
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Catalog No. Quantity
PIMA547792 200 μg
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Catalog No. PIMA547792 Supplier Invitrogen™ Supplier No. MA547792
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Description

Mouse Recombinant Monoclonal Antibody

Specificity: Recognises the extracellular domain of the Insulin Receptor alpha.

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
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Specifications

Antigen INSR alpha
Applications ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation
Classification Recombinant Monoclonal
Clone 83-7
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene INSR
Gene Accession No. P06213
Gene Alias 4932439J01Rik; CD220; CD220 beta; D630014A15Rik; DAF-2; HHF5; INSR; insulin receptor; insulin receptor (INSR); insulin receptor precursor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR alpha; IR beta; ir-A; IR-B
Gene Symbols INSR
Host Species Mouse
Immunogen Epitope within amino acids 140-301 (the cysteine rich region) of the extracellular domain of the human Insulin Receptor alpha.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3643
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1 κ
Target Molecule Tag
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