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Invitrogen™ INSR beta Recombinant Rabbit Monoclonal Antibody (SN20-13)
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Catalog No. PIMA542446
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100 μL
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PIMA542446 100 μL
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Catalog No. PIMA542446 Supplier Invitrogen™ Supplier No. MA542446
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Description

Rabbit Recombinant Monoclonal Antibody

Positive Control: MCF-7 cell lysate, 293 cell lysate, HepG2, LO2, RH-35, PANC-1. Subcellular Location: Cell membrane.

Biological actions of insulin and IGF-1 are mediated by their respective cell surface receptor tyrosine kinases that regulate multiple signaling pathways through activation of a series of phosphorylation cascades. The insulin receptor. Insulin/IGF-1 binding to the extracellular domain leads to autophosphorylation of downstream target proteins. These two receptors differ in sequence in regions that confer specificity for the designated ligand as well as in certain intracellular signaling domains, resulting in significant differences in the functional consequences of activation of each receptor. Defects in IR are the cause of various insulin resistance syndromes and IGF-1R defects may cause some forms of growth retardation. Both these signaling cascades are also important for the development of cancer.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INSR beta
Applications Immunohistochemistry (Paraffin), Western Blot, Immunocytochemistry
Classification Recombinant Monoclonal
Clone SN20-13
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation TBS with 0.05% BSA, 40% glycerol and 0.05% sodium azide; pH 7.4
Gene INSR
Gene Accession No. P06213, P15127, P15208
Gene Alias 4932439J01Rik; CD220; CD220 beta; CD221; D630014A15Rik; HHF5; IGF-I receptor; Insr; Insulin receptor; insulin receptor preproprotein; Insulin receptor subunit alpha; Insulin receptor subunit beta; IR; IR beta; IR-A; IR-B
Gene Symbols INSR
Host Species Rabbit
Immunogen Synthetic peptide within human Insulin receptor aa 930-970.
Purification Method Protein A
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16337, 24954, 3643
Target Species Human, Mouse, Rat
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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