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Invitrogen™ Insulin Monoclonal Antibody (IN-05)
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Catalog No. PIMA544059
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Quantity:
100 μg
Catalog No. Quantity
PIMA544059 100 μg
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Catalog No. PIMA544059

Supplier: Invitrogen™ MA544059

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Description

Mouse Monoclonal Antibody

This antibody reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma. Functional application: The antibody blocks binding of insulin to the receptor.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
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Specifications

Antigen Insulin
Applications ELISA, Functional Assay, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Immunocytochemistry
Classification Monoclonal
Clone IN-05
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative; pH 7.4
Gene INS
Gene Accession No. P01308, P01315, P01317
Gene Alias AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
Gene Symbols INS
Host Species Mouse
Immunogen Porcine insulin.
Purification Method Protein A
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 280829, 3630, 397415
Target Species Human, Bovine, Pig
Content And Storage 4°C, do not freeze
Product Type Antibody
Form Liquid
Isotype IgG1
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