Invitrogen™ Insulin Monoclonal Antibody (IN-05)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA544059

Catalog No. PIMA544059

Description

This antibody reacts with insulin, one of the major regulatory endocrine hormones of intermediate metabolism, normally secreted by the beta cells (a type of islet cells) of the pancreas; it is also present in tumors of B cell origin such as insulinoma. Functional application: The antibody blocks binding of insulin to the receptor.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.

Specifications

• Antigen: Insulin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative; pH 7.4
• Gene Accession No.: P01308, P01315, P01317
• Gene Symbols: INS
• Immunogen: Porcine insulin.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Bovine, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: ELISA, Functional Assay, Immunohistochemistry (Paraffin), Radioimmune Assays (RIA), Immunocytochemistry
• Clone: IN-05
• Conjugate: Unconjugated
• Gene: INS
• Gene Alias: AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
• Host Species: Mouse
• Purification Method: Protein A
• Regulatory Status: RUO
• Gene ID (Entrez): 280829, 3630, 397415
• Content And Storage: 4°C, do not freeze
• Form: Liquid