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Insulin Monoclonal Antibody (INS04 (E2-E3)), Invitrogen™

Catalog No. PIMA512032
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500 μL
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Catalog No. Quantity
PIMA512032 500 μL
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Catalog No. PIMA512032 Supplier Thermo Scientific Supplier No. MA512032
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Description

Mouse Monoclonal Antibody

MA5-12032 targets Insulin in immunohistochemistry (paraffin) applications and shows reactivity with human samples. The MA5-12032 immunogen is swine insulin.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Insulin
Applications Immunohistochemistry (Paraffin)
Classification Monoclonal
Clone INS04 (E2-E3)
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.2% BSA and 0.09% sodium azide; pH 7.4
Gene INS
Gene Accession No. P01308, P01315
Gene Alias AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
Gene Symbols INS
Host Species Mouse
Immunogen Swine insulin
Purification Method Protein G
Quantity 500 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3630, 397415
Target Species Human, Pig
Content And Storage 4° C
Product Type Antibody
Form Liquid
Isotype IgG1 κ
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