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Invitrogen™ Insulin/Proinsulin Monoclonal Antibody (D6C4 (5E4/3))
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Catalog No. PIMA183255
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200 μg
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PIMA183255 200 μg
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Catalog No. PIMA183255 Supplier Invitrogen™ Supplier No. MA183255
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Description

Mouse Monoclonal Antibody

This product has an Affinity of 8.1x10^8 M^-1 . Mouse anti Human Insulin/Proinsulin antibody, clone D6C4 (5E4/3), recognizes both the pro and mature forms of human insulin but does not react with free C-peptide.

Insulin is a peptide hormone secreted by beta cells of the pancreatic islets. It regulates carbohydrate, protein and lipid metabolism by enhancing membrane transport of glucose, amino acids, and certain ions. It also promotes glycogen storage, formation of triglycerides and synthesis of proteins and nucleic acids. Insulin is 51-amino acid polypeptide product produced from a precursor peptide, proinsulin. Proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds and one molecule of C-peptide. Insulin deficiency results in diabetes mellitus, one of the leading causes of morbidity and mortality in the general population. Insulin is also present in tumors of b-cell origin such as insulinoma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Insulin/Proinsulin
Applications ELISA, Immunohistochemistry (Frozen)
Classification Monoclonal
Clone D6C4 (5E4/3)
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with <0.1% sodium azide
Gene INS
Gene Accession No. P01308, P01315, P01317, P01322, P01323, P01325, P01326
Gene Alias AA986540; IDDM; IDDM1; IDDM2; ILPR; INS; Ins1; Ins-1; Ins2; Ins-2; Ins2-rs1; InsII; Insulin; insulin 1; insulin 2; Insulin A chain; Insulin B chain; insulin I; insulin II; insulin-1; Insulin-1 A chain; Insulin-1 B chain; Insulin-2; Insulin-2 A chain; Insulin-2 B chain; IRDN; Mody; MODY10; Mody4; preproinsulin; proinsulin
Gene Symbols INS, Ins1, Ins2
Host Species Mouse
Immunogen Recombinant human insulin.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16333, 16334, 24505, 24506, 280829, 3630, 397415
Target Species Human, Mouse, Rat, Bovine, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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