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Integrin β7 Chain Rat anti-Mouse, Brilliant Violet 786, Clone: M293, BD Optibuild™

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BDB743792 50 μg
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Catalog No. BDB743792 Supplier BD Biosciences Supplier No. 743792
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Description

Rat Monoclonal Antibody

The M293 monoclonal antibody specifically recognizes the integrin ß7 chain (also known as integrin ßp), which is found in association with either of twoαchains.α4ß7 (LPAM-1) is expressed on most mature lymphocytes and on small subsets of thymic and bone marrow cells; it interacts with several ligands, including VCAM-1, fibronectin, and MAdCAM-1.αIELß7 is found primarily on intestinal mucosal and intraepithelial lymphocytes (IEL), and it may be primarily involved in interactions between IEL and epithelia via /recognition of E-cadherin. The epitope recognized by the mAb M293 has been mapped to the region between amino acids 387 and 542. The M293 antibody exhibits little or no activity in blocking ß7 integrin-mediated adhesion.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin β7 Chain
Classification Monoclonal
Clone M293
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Itgb7, Integrin βp, Integrin beta-P, Integrin beta-7, Ly69, M290 IEL Ag
Host Species Rat
Immunogen αIELβ7 integrin from the C57BL/10 mouse T-cell hybridoma MTC-1
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Mouse
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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