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Integrin β7 Rat, Brilliant Violet 510, Clone: FIB504, BD Optibuild™

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BDB744011 50 μg
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Catalog No. BDB744011 Supplier BD Biosciences Supplier No. 744011
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Description

Rat Monoclonal Antibody

The FIB504 monoclonal antibody specifically recognizes mouse integrin β 7 subunit (130 kDa) but also crossreacts with human integrin β 7. Integrin β 7 associates with α 4 (CD49d) expressed on subsets of lymphocytes and thymocytes. It also associates with α IEL (CD103) expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Integrin β 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leucocytes to extravascular spaces during the inflammatory response.

The antibody was conjugated to BD Horizon™ BV510 which is part of the BD Horizon Brilliant™ Violet family of dyes. With an Ex Max of 405nm and Em Max at 510nm, BD Horizon BV510 can be excited by the violet laser and detected in the BD Horizon V500 (525/50nm) filter set. BD Horizon BV510 conjugates are useful for the detection of dim markers off the violet laser. BV510 is a polymer-based dye that is brighter than BD Horizon V500. Due to similar excitation and emission properties, BD Horizon BV510 and BD Horizon V500 cannot be used simultaneously.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin β7
Classification Monoclonal
Clone FIB504
Concentration 0.2mg/mL
Conjugate Brilliant Violet 510
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Itgb7, Integrin β7, Integrin beta 7, ITB7, Ly-69, Ly69
Host Species Rat
Immunogen Mouse T lymphoma line TK1
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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Safety and Handling

WARNING: Reproductive Harm - www.P65Warnings.ca.gov
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