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Integrin β7 Rat, BUV395, Clone: FIB504, BD Optibuild™

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BDB744014 50 μg
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Catalog No. BDB744014 Supplier BD Biosciences Supplier No. 744014
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Description

Rat Monoclonal Antibody

The FIB504 monoclonal antibody specifically recognizes mouse integrinβ7 subunit (130 kDa) but also crossreacts with human integrinβ7. Integrinβ7 associates withα4 (CD49d) expressed on subsets of lymphocytes and thymocytes. It also associates withαIEL (CD103) expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Integrinβ7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leucocytes to extravascular spaces during the inflammatory response.

The antibody was conjugated to BD Horizon™ BUV395 which is part of the BD Horizon Brilliant™ Ultraviolet family of dyes. This dye has been exclusively developed by BD Biosciences to have minimal spillover into other detectors, making it an optimal choice for multicolor flow cytometry. With an Ex Max at 348 nm and an Em Max at 395 nm, BD Horizon BUV395 can be excited with a 355 nm laser and detected with a 379/28 filter. BUV395 is a UV-excitable dye that has been developed exclusively by BD Biosciences. With an excitation max of 348 nm and emission max of 395 nm, BUV395 can be excited by the 355nm laser and detected in a 379/28 filter. This dye is optimal for multicolor flow cytometry because it has little to no spillover into other detectors.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin β7
Classification Monoclonal
Clone FIB504
Concentration 0.2mg/mL
Conjugate Brilliant Ultraviolet 395
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Itgb7, Integrin β7, Integrin beta 7, ITB7, Ly-69, Ly69
Host Species Rat
Immunogen Mouse T lymphoma line TK1
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2a κ
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