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Integrin alpha-6 Rabbit anti-Human, Polyclonal, Proteintech
SDP

Catalog No. 501735593 Shop All Proteintech Group Inc Products
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50-173-5593 150 μL
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Catalog No. 50-173-5593 Supplier Proteintech Group Inc Supplier No. 271891AP150UL
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Description

Rabbit Polyclonal Antibody

E3 ubiquitin-protein ligase that mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint. May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome. In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53. Plays a role in RPA-mediated DNA damage signaling and repair.

Specifications

Antigen Integrin alpha-6
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.23 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
Gene ITGA6
Gene Accession No. P23229
Gene Alias CD49f, Integrin alpha 6, Integrin alpha-6, integrin, alpha 6, ITGA6, ITGA6B, VLA 6
Gene Symbols ITGA6
Host Species Rabbit
Immunogen Integrin alpha-6 Fusion Protein Ag25835
Purification Method Antigen Affinity Chromatography
Quantity 150 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 3655
Target Species Human
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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