MilliporeSigma™ Integrin beta-1 (CD29), Mouse, Unlabeled, Clone: 13C4.1,

Mouse Monoclonal Antibody

Supplier:  MilliporeSigma™ MABT529

Catalog No. MABT529

Description

Integrin beta-1 (UniProt P05556; also known as CD29, Glycoprotein Iia, GPIIA, Integrin VLA-4 subunit beta, Very late activation protein, beta polypeptide) is encoded by the ITGB1 (also known as FNRB, MDF2, MSK12, VLA-BETA, VLAB) gene (Gene ID 3688) in human. Integrin beta-1 is a 130kDa transmembrane glycoprotein that interact with various integrin alpha subunits (including alpha 1, alpha 2, alpha 3, alpha 4, alpha 5, and alpha 6) to form the functional receptor complexes that bind to specific extracellular matrix proteins. Integrin receptors regulate a variety of important biological functions, including embryonic development, wound repair, hemostasis, and prevention of programmed cell death. They are also implicated in abnormal pathological states such as tumor directed angiogenesis, tumor growth and metastasis. These heterodimeric receptors bridge the cytoplasmic actin cytoskeleton with proteins present in the extracellular matrix and/or on adjacent cells. Interactions between integrins and the extracellular matrix lead to the activation of signal transduction pathways and regulation of gene expression.

Specifications

• Antigen: Integrin beta-1 (CD29)
• Classification: Monoclonal
• Concentration: Please refer to lot specific datasheet.
• Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene Accession No.: P05556
• Immunogen: GST-tagged recombinant human Integrin beta-1 fragment corresponding to the membrane-proximal extracellular region.
• Quantity: 100 μL
• Research Discipline: Cell Structure
• Gene ID (Entrez): NP_002202
• Target Species: Human
• Form: Purified

• Applications: Western Blot
• Clone: 13C4.1
• Conjugate: Unconjugated
• Gene: ITGB1, FNRB, MDF2, MSK12, VLA-BETA, VLAB
• Host Species: Mouse
• Purification Method: Protein G Purified
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Test Specificity: Clone 13C4.1 targets an epitope within the membrane-proximal extracellular region present in all five spliced isoforms of human Integrin beta-1 reported by UniPort (P05556).
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Isotype: IgG1 λ

For Research Use Only. Not for use in diagnostic procedures.