Integrin beta 4/CD104 Antibody (UM-A9), Novus Biologicals™

Mouse Monoclonal Antibody

Catalog Number	Mfr. No.	Quantity
NBP232813F	Novus Biologicals NBP2328130.02MG	0.02 mg
NBP232813A	Novus Biologicals NBP2328130.1MG	0.1 mg
NBP232813B	Novus Biologicals NBP2328130.2MG	0.2 mg

Description

Integrin beta 4/CD104 Monoclonal specifically detects Integrin beta 4/CD104 in Human samples. It is validated for Flow Cytometry, Immunocytochemistry/Immunofluorescence.

Specifications

• Antigen: Integrin beta 4/CD104
• Dilution: Western Blot 0.5-1ug/ml, Flow Cytometry 0.5-1ug/million cells, Immunocytochemistry/Immunofluorescence 0.5-1ug/ml, Immunoprecipitation 0.5-1ug/500ug protein lysate, SDS-Page
• Classification: Monoclonal
• Form: Purified
• Regulatory Status: RUO
• Target Species: Human
• Gene Accession No.: P16144
• Gene ID (Entrez): 3691
• Immunogen: Human squamous cell carcinoma (UM-SCC1)
• Primary or Secondary: Primary
• Content And Storage: Store at 4C.
• Molecular Weight of Antigen: 205 kDa

• Clone: UM-A9
• Applications: Western Blot, Flow Cytometry, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, SDS-Page
• Conjugate: Unconjugated
• Host Species: Mouse
• Research Discipline: Adaptive Immunity, Immunology, Phospho Specific, Signal Transduction
• Formulation: PBS with 0.05% BSA. with 0.05% Sodium Azide
• Gene Alias: CD104, CD104 antigen, GP150, integrin beta-4, integrin beta-4 subunit, integrin, beta 4
• Gene Symbols: ITGB4
• Isotype: IgG2a κ
• Purification Method: Protein A purified
• Test Specificity: Recognizes a protein of 205kDa, which is identified as integrin beta-4 (ITGB4). Its epitope is localized in the extracellular domain of ITGB4 protein. Integrins are heterodimers comprised of alpha and beta subunits, that are non-covalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta-4 subunit, a receptor for the laminins. This subunit tends to associate with alpha-6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.