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Invitrogen™ Integrin beta 7 Chimeric Recombinant Rabbit Monoclonal Antibody (FIB27)
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Catalog No. PIMA548015
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200 μg
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Catalog No. Quantity
PIMA548015 200 μg
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Catalog No. PIMA548015 Supplier Invitrogen™ Supplier No. MA548015
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Description

Rabbit Recombinant Monoclonal Antibody

Specificity: FIB27 binds specifically to both human and mouse integrin beta-7 at epitope region Dl on which is involved in all a4b7-mediated adhesion events. Does not compete with DAKT32 for binding. FIB27 blocks LS722-induced TK1 cell aggregation (mAb LS722 is an activating anti-a4B7 antibody and induces aggregation via an a4B7-dependent pathway).

Integrin beta 7 associates with integrin alpha 4 (CD49d) to form the alpha 4 beta 7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alpha E (CD103) to form the alpha E beta 7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Ligands for LPAM-1 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the ligand of HML-1 is E-cadherin (CD324). Integrin beta 7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin beta 7 Chimeric
Applications Flow Cytometry, Inhibition Assays, Immunoprecipitation, Immunocytochemistry
Classification Recombinant Monoclonal
Clone FIB27
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 0.02% ProClin 300
Gene ITGB7
Gene Accession No. P26010, P26011
Gene Alias Gut homing receptor beta subunit; integrin beta 7; integrin beta 7 subunit; integrin beta-7; Integrin beta-P; integrin subunit beta 7; integrin, beta 7; ITGB7; Ly69; M290 IEL antigen
Gene Symbols ITGB7
Host Species Rabbit
Immunogen FIB27 was prepared by immunizing rats with TK1 cells.
Purification Method Protein A
Quantity 200 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 16421, 3695
Target Species Human, Mouse
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG κ
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