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Integrin αvβ5 Mouse, Brilliant Violet 786, Clone: ALULA, BD Optibuild™

Catalog No. BDB743674 Shop All BD Biosciences Products
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BDB743674 50 μg
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Catalog No. BDB743674 Supplier BD Biosciences Supplier No. 743674
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Description

Mouse Monoclonal Antibody

The ALULA monoclonal antibody specifically binds to Integrin alpha v beta 5 (αvβ5), which is also known asCD51/β5.Integrin αvβ5 is widely expressed byfibroblasts, endothelial cells, and vascular smooth muscle cells. It is involved in activation-dependent cell migration and cell adhesion to the extracellular matrix. Integrin αvβ5 plays a major role in growth factor-induced angiogenesis in response to VEGF and TGF.The αv Integrins, αvβ5andαvβ3,αre involved in tumor growthand are being targeted in cancer therapies. The ALULA clone specificallyrecognizes αvβ5 integrin and functionally blocks the interaction between αvβ5 and vitronectin.Although raised against mouseαvβ5, the ALULA antibody crossreacts with humanαvβ5.

The antibody was conjugated to BD Horizon™ BV786 which is part of the BD Horizon Brilliant™ Violet family of dyes. This dye is a tandem fluorochrome of BD Horizon BV421 with an Ex Max of 405nm and an acceptor dye with an Em Max at 786nm. BD Horizon BV786 can be excited by the violet laser and detected in a filter used to detect Cy™7-like dyes (eg, 780/60nm filter). BV786 is a tandem fluorochrome of BD Horizon BV421 and an acceptor dye with an emission maximum at 786 nm. BV786 offers a bright choice for the 6th detector off the violet laser.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Integrin αvβ5
Classification Monoclonal
Clone ALULA
Concentration 0.2mg/mL
Conjugate Brilliant Violet 786
Formulation Aqueous buffered solution containing ≤0.09% sodium azide.
Gene Alias Integrin alpha v beta 5, αVβ5, CD51/β5
Host Species Mouse
Immunogen Mouse fibroblasts expressing αvβ5
Purification Method Affinity Purified
Quantity 50 μg
Regulatory Status RUO
Primary or Secondary Primary
Target Species Human
Content And Storage Store undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.
Isotype IgG2b κ
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