Invitrogen™ Interferon alpha-2 Monoclonal Antibody (N39)

Mouse Monoclonal Antibody

Supplier:  Invitrogen™ MA135514

Catalog No. 01-671-354

Description

The alpha interferons are involved in virus resistance in target cells for these viruses. They are known to block cell proliferation and to regulate MHC class I antigen expression. The IFNα family has over 20 genes and pseudogenes in two families (I and II), one with a mature length of 166aa and one of 172aa. Cells producing IFNα are lymphocytes, monocytes, macrophages and cell lines such as Namalwa and KGI. Bioassays for IFNα include cytopathic effect blocking, by viruses such as VSV, SFV and BMCV, on their target cells. A number of receptors for IFNα are now known and seem to be expressed on most cell types. N39 is specific for human IFNα2 and does not cross react with human IFNα1. N39 is directed against immunodominant epitope site I (aa112-148).

IFN alpha (Interferon alpha) is a Type I interferon belonging to a family of structurally related, species-specific proteins exclusive to vertebrates. The interaction of IFN-alpha with its receptor component result in the activation of a number of signaling pathways which are mainly involved in innate immune response against viral infection. In humans, the gene for IFN alpha is located on on chromosome 9. The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. IFN alpha is produced primarily by plasmacytoid dendritic cells, is a potent component of the anti-viral innate immune response and modulates adaptive immunity. Diseases associated with the dysfunction of IFN alpha include Hepatitis C and Hepatitis.

Specifications

• Antigen: Interferon alpha-2
• Classification: Monoclonal
• Concentration: 100 μg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: P01563
• Gene Symbols: IFNA2
• Immunogen: E. coli derived recombinant human IFN alpha2c.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG1 κ

• Applications: ELISA, Neutralization, Western Blot
• Clone: N39
• Conjugate: Unconjugated
• Gene: IFNA2
• Gene Alias: alpha-2a interferon; Ifa2; IFNA; IFN-a; IFNA 2; Ifna2; IFNA2A; IFNA2B; IFNA2C; IFN-alpha 1b; IFN-alpha-1/13; IFN-alpha-2; IFN-alphaA; INFA2; Interferon; interferon alpha 1b; interferon alpha 2; interferon alpha 2a; interferon alpha 2b; interferon alpha A; interferon alpha family, gene 2; interferon alpha-2; Interferon alpha-A; interferon alpha-D; interferon, alpha 2; Interferon-alpha II; leIF A; leIF D; RP11-354P17.2
• Host Species: Mouse
• Purification Method: purified
• Regulatory Status: RUO
• Gene ID (Entrez): 3440
• Content And Storage: 4°C
• Form: Liquid

Safety and Handling

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