Interferon beta Polyclonal Antibody, Rockland™

Rabbit Polyclonal Antibody

Catalog Number	Mfr. No.	Quantity
50-199-1526	Rockland Immunochemicals 214401C40	100 μg
50-199-1527	Rockland Immunochemicals 214401C40S	25 μL

Description

Store vial at 4°C prior to restoration. For extended storage aliquot contents and freeze at -20°C or below. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. This antibody is specific for swine IFN beta protein. A BLAST analysis was used to suggest cross-reactivity with IFN beta from Sus scrofa (pig), Potamochoerus larvatus koiropotamus, Potamochoerus larvatus (Bushpig), and Phacochoerus africanus (warthog) sources based on 100% homology with the immunizing sequence. Cross-reactivity with IFN beta from other sources has not been determined.

Type I Interferons (IFN-alpha/beta) are produced primarily in response to viral infection by Natural IFN-producing cells (IPCs) as part of the host immune response. IFNs can also inhibit the development of tumors. IFN-beta binding results in the activation of the tyrosine kinases Jak1 and Tyk2, phosphorylation of members of the STAT family of transcription factors, and the transcription and expression of the immune response genes. More recently, several members of the toll-like receptor (TLR) family were found to stimulate the production IFN-beta. IFN-beta is currently used clinically for treatment of tumors, infections and multiple sclerosis.

Specifications

• Antigen: Interferon beta
• Applications: ELISA, Immunoprecipitation, Western Blot
• Conjugate: Unconjugated
• Host Species: Rabbit
• Target Species: Pig
• Gene Alias: Fibroblast interferon; Ifb; IFF; IFN b; IFN ß; Ifnb; IFNB1; IFNbeta; IFN-beta; IFNß; Interferon b; Interferon beta; interferon beta 1; interferon beta 1, fibroblast; interferon, beta 1; interferon, beta 1, fibroblast; interferon-beta; RP11-113D19.1
• Gene Symbols: Ifnb1
• Primary or Secondary: Primary
• Product Type: Antibody

• Concentration: 1 mg/mL
• Classification: Polyclonal
• Form: Lyophilized
• Regulatory Status: RUO
• Formulation: 0.02M potassium phosphate with 0.15M NaCl and 0.01% sodium azide; pH 7.2
• Gene ID (Entrez): 445459
• Immunogen: This protein A purified antibody was prepared from whole rabbit antiserum produced by repeated immunizations with a recombinant protein raised in yeast corresponding to 164 amino acids of the mature swine IFN beta protein.
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Gene: Ifnb1