MilliporeSigma™ INTS1, Mouse, Unlabeled, Clone: 4.47,

Catalog No.	Quantity	Conjugate
MABS1984MI	100 μg	Unconjugated

Catalog No. MABS1984MI Supplier MilliporeSigma™ Supplier No. MABS1984

Description

Mouse Monoclonal Antibody

Integrator complex subunit 1 (UniProt Q8N201; also known as Int1) is encoded by the INTS1 (also known as KIAA1440, UNQ1821/PRO3434) gene (Gene ID 26173) in human. INTS1 is a large protein that is a component of the integrator complex that is involved in small nuclear RNAs U1 and U2 transcription and their 3&prime-box-dependent processing. During transcriptional regulation and in RNA processing, it directly binds to the C-terminal domain of the RNA polymerase II largest subunit. It has been reported that INTS1 is also involved in different cell support processes, such as the formation of a scaffold for the assembly of integrator complex. Developing INTS1 (-/-) mouse embryos show growth arrest at the early blastocyst stage and exhibit activated caspase-3 and caspase-7 that induce apoptosis within the inner cell mass of blastocyst.

Specifications

• Antigen: INTS1
• Applications: Western Blot
• Classification: Monoclonal
• Clone: 4.47
• Concentration: Please refer to lot specific datasheet.
• Conjugate: Unconjugated
• Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
• Gene: INTS1, KIAA1440, UNQ1821/PRO3434
• Gene Accession No.: Q8N201
• Host Species: Mouse
• Immunogen: GST-tagged recombinant human INTS1 internal fragment.
• Purification Method: Protein G Purified
• Quantity: 100 μg
• Regulatory Status: RUO
• Research Discipline: Epigenetics & Nuclear Function
• Primary or Secondary: Primary
• Gene ID (Entrez): NP_001073922
• Test Specificity: Clone 4.47 targets an epitope in the central region of human INTS1 protein.
• Target Species: Human
• Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
• Form: Purified
• Isotype: IgG1 κ

For Research Use Only. Not for use in diagnostic procedures.