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Invitrogen™ INTS3 Polyclonal Antibody
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Catalog No. PIPA5100577
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100 μL
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PIPA5100577 100 μL
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Catalog No. PIPA5100577 Supplier Invitrogen™ Supplier No. PA5100577
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Description

Rabbit Polyclonal Antibody

Antibody detects endogenous levels of total INTS3.

Component of the Integrator complex. The Integrator complex is involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. The Integrator complex is associated with the C-terminal domain (CTD) of RNA polymerase II largest subunit (POLR2A) and is recruited to the U1 and U2 snRNAs genes.; FUNCTION: Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. The SOSS complex is required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs) and ATM-dependent signaling pathways. In the SOSS complex, it is required for the assembly of the complex and for stabilization of the complex at DNA damage sites.
TRUSTED_SUSTAINABILITY

Specifications

Antigen INTS3
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene INTS3
Gene Accession No. Q68E01, Q7TPD0
Gene Alias C1orf193; C1orf60; C77668; INT3; integrator complex subunit 3; Ints3; RGD1304593; Sensor of single-strand DNA complex subunit A; sensor of ssDNA subunit A; SOSS complex subunit A; SOSSA; SOSS-A
Gene Symbols INTS3
Host Species Rabbit
Immunogen A synthesized peptide derived from human INTS3(Accession Q68E01), corresponding to amino acid residues P503-R553.
Purification Method Affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 229543, 361988, 65123
Target Species Human, Mouse, Rat
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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