Invitrogen™ INTU Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA535900

Catalog No. PIPA535900

Description

Recommended positive controls: Mouse brain. Predicted reactivity: Bovine (89%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

Plays a key role in ciliogenesis and embryonic development. Regulator of cilia formation by controlling the organization of the apical actin cytoskeleton and the positioning of the basal bodies at the apical cell surface, which in turn is essential for the normal orientation of elongating ciliary microtubules. Plays a key role in definition of cell polarity via its role in ciliogenesis but not via conversion extension. Has an indirect effect on hedgehog signaling. Proposed to function as core component of the CPLANE (ciliogenesis and planar polarity effectors) complex involved in the recruitment of peripheral IFT-A proteins to basal bodies (PubMed:27158779). [UniProt].

Specifications

• Antigen: INTU
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: INTU
• Gene Alias: 9230116I04Rik; 9430087H23Rik; homolog of inturned; INT; Intu; Inturned planar cell polarity effector homolog; inturned planar cell polarity effector homolog (Drosophila); inturned planar cell polarity protein; KIAA1284; mKIAA1284; PDZ domain containing 6; PDZ domain-containing protein 6; PDZD6; PDZK6; Protein inturned
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 27152, 380614
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 20% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q059U7, Q9ULD6
• Gene Symbols: INTU
• Immunogen: Recombinant fragment corresponding to a region within amino acids 693 and 942 of INTU.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov