Involucrin Monoclonal Antibody (SY8), Invitrogen™

Mouse Monoclonal Antibody

Supplier:  Thermo Scientific MA190573

Catalog No. PIMA190573

Description

MA1-90573 detects Involucrin from non-human primate, porcine, and human samples.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Specifications

• Antigen: Involucrin
• Classification: Monoclonal
• Concentration: 1 mg/mL
• Formulation: PBS with no preservative
• Gene Accession No.: P07476, P18174, P18175
• Gene Symbols: IVL
• Immunogen: Pure involucrin from human keratinocytes.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Avian, Canine, Human, Non-human Primate, Pig
• Product Type: Antibody
• Isotype: IgG1

• Applications: Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
• Clone: SY8
• Conjugate: Unconjugated
• Gene: IVL
• Gene Alias: 1110019C06Rik; involucrin; IVL
• Host Species: Mouse
• Purification Method: Protein G
• Regulatory Status: RUO
• Gene ID (Entrez): 101125010, 102152041, 3713, 407242
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid