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Involucrin Monoclonal Antibody (SY8), Invitrogen™

Catalog No. PIMA190573
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100 μg
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Catalog No. Quantity
PIMA190573 100 μg
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Catalog No. PIMA190573 Supplier Thermo Scientific Supplier No. MA190573

Description

Mouse Monoclonal Antibody

MA1-90573 detects Involucrin from non-human primate, porcine, and human samples.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.
TRUSTED_SUSTAINABILITY

Specifications

Antigen Involucrin
Applications Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Classification Monoclonal
Clone SY8
Concentration 1 mg/mL
Conjugate Unconjugated
Formulation PBS with no preservative
Gene IVL
Gene Accession No. P07476, P18174, P18175
Gene Alias 1110019C06Rik; involucrin; IVL
Gene Symbols IVL
Host Species Mouse
Immunogen Pure involucrin from human keratinocytes.
Purification Method Protein G
Quantity 100 μg
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 101125010, 102152041, 3713, 407242
Target Species Avian, Canine, Human, Non-human Primate, Pig
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG1
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