Invitrogen™ Involucrin Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA586160

Catalog No. PIPA586160

Description

Purity is > 95% by SDS-PAGE.

Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures it is expressed by all cells that have left the basal layer. Involucrin expression is abnormal in squamous cell carcinomas and premalignant lesions and is reduced in severe dysplasias of the larynx and cervix. Its gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.

Specifications

• Antigen: Involucrin
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IVL
• Gene Alias: 1110019C06Rik; involucrin; IVL
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 16447, 3713, 60583
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Western Blot
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: P07476, P48997, P48998
• Gene Symbols: IVL
• Immunogen: Synthetic peptide, corresponding to amino acids 541-585 of Human Involucrin.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov