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Tocris Bioscience™ IOX 1
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Catalog No. 446450
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44-645-0 50 mg
44-641-0 10 mg
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Catalog No. 44-645-0 Supplier Tocris Bioscience™ Supplier No. 4464/50
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Description

Histone demethylase inhibitor; cell permeable

IOX 1 is a histone demethylase JMJD inhibitor (IC50 values are 0.12, 0.17, 0.2, 0.3, 0.6 and 1 μM for JMJD3, JMJD1A, JMJD2A, JMJD2E, JMJD2C and UTX respectively). Cell permeable; it inhibits JMJD2A-mediated H3K9me3 demethylation in HeLa cells. IOX 1 suppresses IL-17 expression in mouse and human CD4+ T cells by targeting TET2. It also reduces infiltration of Th17 cells in an in vivo model of intraocular inflammation.

Chemical Identifiers

CAS 5852-78-8
Molecular Formula C10H7NO3

Specifications

Quantity 50 mg
Formula Weight 189.17
Purity >99%
Molecular Weight (g/mol) 189.17
Chemical Name or Material IOX 1

Safety and Handling

Recommended Storage Store at +4°C
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