Invitrogen™ IP6K2 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA549891

Catalog No. PA549891

Description

The antibody detects endogenous levels of total IP6K2 protein.

The members of the inositol hexakisphosphate kinase family, IP6K1 and IP6K2, have a high affinity and selectivity for inositol hexakisphosphate (InsP6) as a substrate. IP6K1 and IP6K2 (also designated PiUS) convert InsP6 to PP-InsP5. However, neither kinase demonstrates any catalytic activity with other inositol pyrophosphates. The presence of InsP6, which inhibits serine/threonine protein phosphatases, increases the influx of calcium across the plasma membrane and implies that it may mediate the regulation of insulin exocytosis. IP6K1 was purified as a 54 kDa protein in rat brain extracts. By homology, IP6K1 and IP6K2 were characterized in mouse as a 50 kDa and 49 kDa protein, respectively. IP6K1 displays ATP synthase activity by transferring a phosphate from PP-InsP5 to ADP, which suggests a role for the IP6 kinases as high energy phosphate donors.

Specifications

• Antigen: IP6K2
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: Ip6k2
• Gene Alias: 1500005N04Rik; ATP:1D-myo-inositol-hexakisphosphate phosphotransferase; AW050208; Ihpk2; Inositol hexakisphosphate kinase 2; inositol hexaphosphate kinase 2; inositol-hexakisphosphate kinase; insp6 kinase 2; IP6 Kinase; IP6K2; P(i)-uptake stimulator; pi uptake stimulator; Pius; TCCCIA00113
• Host Species: Rabbit
• Purification Method: Antigen Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 51447, 59268, 76500
• Content And Storage: -20°C
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
• Gene Accession No.: Q80V72, Q9R0U1, Q9UHH9
• Gene Symbols: Ip6k2
• Immunogen: Synthesized peptide derived from internal of human IP6K2.
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG