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Importin 4 Rabbit anti-Human, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550433

Catalog No. PA550433


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Description

Description

The antibody detects endogenous levels of total IPO4 protein.

Importin-4 is a protein that in humans is encoded by the IPO4 gene. Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran.
Specifications

Specifications

Importin 4
Polyclonal
Unconjugated
IPO4
Liquid
IPO4
Fusion protein corresponding to residues near the C terminal of human importin 4
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human
Immunohistochemistry (Paraffin), Western Blot
2.4 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q8TEX9
IMP4B, RANBP4
Rabbit
IgG
100 μL
-20°C
Primary
79711
Documents
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