IQGAP1 Monoclonal Antibody (OTI6E10), TrueMAB™, OriGene

Catalog No.	Quantity
50-168-3082	100 μL

Catalog No. 50-168-3082 Supplier OriGene Supplier No. TA809894

Description

Mouse Monoclonal Antibody

DISP2 is the second of three known homologs of the D. melanogaster protein Dispatched. It is a multi-transmembrane protein containing two PTCH/DISP domains and is thought to be involved in the release of lipid-anchored Hedgehog from producing cells. Hedgehog is a major player in signaling pathways during embryogenesis, tissue regeneration, and carcinogenesis and the DISP proteins have been implicated in these pathways. Recently, it has been shown that DISP2 is translationally regulated by the microRNA miR-214 in zebrafish. Expression of this miRNA decreased DISP2 promoter activity in vitro and its overexpression in zebrafish resulted in a phenotype identical to that observed by DISP2 mutants.

Specifications

• Antigen: IQGAP1
• Applications: Immunohistochemistry (Paraffin), Western Blot
• Classification: Monoclonal
• Clone: OTI6E10
• Concentration: 1 mg/mL
• Conjugate: Unconjugated
• Formulation: PBS with 1% BSA, 50% glycerol and 0.02% sodium azide
• Gene: IQGAP1
• Gene Accession No.: P46940
• Gene Alias: HUMORFA01, SAR1, p195
• Gene Symbols: IQGAP1
• Host Species: Mouse
• Immunogen: Human recombit protein fragment corresponding to amino acids 464-609 of human IQGAP1 produced in E.coli.
• Purification Method: Affinity Chromatography
• Quantity: 100 μL
• Regulatory Status: RUO
• Primary or Secondary: Primary
• Gene ID (Entrez): 8826
• Target Species: Human
• Content And Storage: -20° C, Avoid Freeze/Thaw Cycles
• Product Type: Antibody
• Form: Liquid
• Isotype: IgG1