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Invitrogen™ IQGAP3 Polyclonal Antibody
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Catalog No. PIPA556363
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100 μL
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PIPA556363 100 μL
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Catalog No. PIPA556363 Supplier Invitrogen™ Supplier No. PA556363
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: SALLLPAAGL DDVSLPVAPR YHLLLVAAKR QKAQVTGDPG AVLWLEEIRQ GVVRANQDTN TAQRMALGVA AINQAIKEGK AAQTERVL Highest antigen sequence identity to the following orthologs: Mouse - 92%, Rat - 93%.

IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson's disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, malignant melanoma and multiple myeloma.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IQGAP3
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.1 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene IQGAP3
Gene Accession No. Q86VI3
Gene Alias AI593484; D030034H08; IQ motif containing GTPase activating protein 3; IQGA3; IQGAP3; MGC10170; Ras GTPase-activating-like protein IQGAP3
Gene Symbols IQGAP3
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human IQGAP3. Recombinant protein control fragment (Product #RP-94500).
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 128239
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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