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IQGAP3 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550230

Catalog No. PA550230


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Description

Description

The antibody detects endogenous levels of total IQGAP3 protein.

IQGAP3 (IQ motif containing GTPase activating protein 3) is a 1,631 amino acid protein that acts as an effector of Cdc42 and Rac 1, linking their activation to the cytoskeleton during neuronal morphogenesis. A novel member of the IQGAP family, IQGAP3 is highly expressed in brain where it localizes to axons of hippocampal neurons. IQGAP3 contains one Ras-GAP domain, a CH (calponin-homology) domain, four IQ domains and is encoded by a gene located on human chromosome 1, which spans 260 million base pairs, contains over 3,000 genes and comprises nearly 8% of the human genome. Chromosome 1 houses a large number of disease-associated genes, including those that are involved in familial adenomatous polyposis, Stickler syndrome, Parkinson ft.s disease, Gaucher disease, schizophrenia and Usher syndrome. Aberrations in chromosome 1 are found in a variety of cancers, including head and neck cancer, maligt melanoma and multiple myeloma.
Specifications

Specifications

IQGAP3
Polyclonal
Unconjugated
IQGAP3
Liquid
IQGAP3
Fusion protein corresponding to a region derived from internal residues of human IQ motif containing GTPase activating protein 3
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Western Blot
1.7 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q86VI3
IQGA3, IQGAP3, MGC10170
Rabbit
IgG
100 μL
-20°C
Primary
128239, 404710
Documents
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