Invitrogen™ IQSEC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA558267

Catalog No. PIPA558267

Description

Immunogen sequence: PSSETGTSLD SPSAYPQGPL VPGSSLSPDH YEHTSVGAYG LYSGPPGQQQ RTRRPKLQHS TSILRKQAE Highest antigen sequence identity to the following orthologs: Mouse - 91%, Rat - 91%.

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.

Specifications

• Antigen: IQSEC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IQSEC1
• Gene Alias: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; ARF-GEP100; AW561907; BC026481; BRAG2; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; cI-43; D6Ertd349e; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; Iqsec1; Kiaa0763
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 9922
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Immunohistochemistry (Paraffin), Immunocytochemistry
• Concentration: 0.1 mg/mL
• Formulation: PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
• Gene Accession No.: Q6DN90
• Gene Symbols: IQSEC1
• Immunogen: Recombinant protein corresponding to Human IQSEC1. Recombinant protein control fragment (Product #RP-96357).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov