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Invitrogen™ IQSEC1 Polyclonal Antibody
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Catalog No. PIPA558268
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100 μL
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PIPA558268 100 μL
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Catalog No. PIPA558268 Supplier Invitrogen™ Supplier No. PA558268
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Description

Rabbit Polyclonal Antibody

Immunogen sequence: GSLKRQSAYE RSLGGQQGSP KHGPHSGAPK SLPREEPELR PRPPRPLDSH LAINGSANRQ SKSESDYSDG DNDSINSTSN S Highest antigen sequence identity to the following orthologs: Mouse - 94%, Rat - 94%.

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IQSEC1
Applications Immunohistochemistry (Paraffin)
Classification Polyclonal
Concentration 0.2 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene IQSEC1
Gene Accession No. Q6DN90
Gene Alias ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; ARF-GEP100; AW561907; BC026481; BRAG2; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; cI-43; D6Ertd349e; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; Iqsec1; Kiaa0763
Gene Symbols IQSEC1
Host Species Rabbit
Immunogen Recombinant protein corresponding to Human IQSEC1. Recombinant protein control fragment (Product #RP-96356).
Purification Method Antigen Affinity Chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 9922
Target Species Human
Content And Storage Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Product Type Antibody
Form Liquid
Isotype IgG
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Safety and Handling

WARNING: Cancer - www.P65Warnings.ca.gov
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