Invitrogen™ IQSEC1 Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA595835

Catalog No. PIPA595835

Description

Positive Samples: mouse brain, rat brain Immunogen sequence: SFEGPEKVHS SYFEGKQVSV TNDGSQLGAL VSPECGDLSE PTTLKSPAPS SDFADAITEL EDAFSRQVKS LAESIDDALN CRSLHTEEAP ALDAARARDT EPQTALHGMD HRKLDEMTAS YSDVTLYIDE EELSPPLPLS QAGDRPSSTE SDLRLRAGGA APDYWALAHK EDKADTDTSC RSTPSLERQE QRLRVEHLPL L.

ADP ribosylation factors (Arfs) are small GTP-binding proteins known for their role in vesicular transport, where they nucleate the assembly of coat protein complexes at sites of carrier vesicle formation. IQSEC1 (GEP100/BRAG2), a guanine nucleotide exchange protein for ARF6, belongs to the BRAG family and contains one IQ domain, one PH domain and one SEC7 domain. As a known activator of ARF6, IQSEC1 regulates cell surface levels of Beta1 integrin and its knockdown blocked tumour metastasis. IQSEC1 links EGFR signaling to ARF6 activation and may contribute to the cancer metastasis and malignancy.

Specifications

• Antigen: IQSEC1
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IQSEC1
• Gene Alias: ADP-ribosylation factors guanine nucleotide-exchange protein 100; ADP-ribosylation factors guanine nucleotide-exchange protein 2; ARFGEP100; ARF-GEP100; AW561907; BC026481; BRAG2; brefeldin A-resistant ARF-GEF2; brefeldin-resistant Arf-GEF 2 protein; cI-43; D6Ertd349e; GEP100; IQ motif and Sec7 domain 1; IQ motif and SEC7 domain-containing protein 1; Iqsec1; Kiaa0763
• Host Species: Rabbit
• Purification Method: Affinity Chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 232227, 686590
• Content And Storage: -20°C, Avoid Freeze/Thaw Cycles
• Form: Liquid

• Applications: ELISA, Western Blot
• Concentration: 1.25 mg/mL
• Formulation: PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
• Gene Accession No.: Q8R0S2
• Gene Symbols: IQSEC1
• Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 180-380 of human IQSEC1 (NP_0556843).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Mouse, Rat
• Product Type: Antibody
• Isotype: IgG