Invitrogen™ IRAK-M Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA519969

Catalog No. PIPA519969

Description

In Western blot applications, this antibody detects a band at ~68kDa. A suggested positive control is mouse spleen tissue lysate. PA5-19969 can be used with blocking peptide PEP-0094.

IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.

Specifications

• Antigen: IRAK-M
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IRAK3
• Gene Alias: 4833428C18Rik; AI563835; ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IRAK-3; IRAKM; IRAK-M
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11213, 314870, 73914
• Content And Storage: Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C
• Form: Liquid

• Applications: Immunohistochemistry, Western Blot, Immunocytochemistry
• Concentration: 1 mg/mL
• Formulation: PBS with 0.02% sodium azide
• Gene Accession No.: Q8K4B2, Q9Y616
• Gene Symbols: IRAK3
• Immunogen: A peptide corresponding to 16 amino acids from the carboxy terminus of human IRAK-M.
• Quantity: 100 μg
• Primary or Secondary: Primary
• Target Species: Human, Mouse, Rat
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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