Invitrogen™ IRAK-M Polyclonal Antibody

Rabbit Polyclonal Antibody

Supplier:  Invitrogen™ PA521559

Catalog No. PIPA521559

Description

Recommended positive controls: DDDDK-tagged IRAK3-transfected 293T. Predicted reactivity: Mouse (80%), Bovine (84%). Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

IRAK3 serine/threonine kinase or interleukin-1 receptor-associated kinase 3 is a member of the interleukin-1 receptor-associated kinase protein family which are essential components of the Toll/IL-R immune signal transduction pathways. IRAK3 is primarily expressed in monocytes and macrophages and functions as a negative regulator of Toll-like receptor signaling. IRAK3 mediates critical aspects of innate immunity that result in an immunocompromised state during sepsis. Mutations in IRAK3 are associated with a susceptibility to asthma.

Specifications

• Antigen: IRAK-M
• Classification: Polyclonal
• Conjugate: Unconjugated
• Gene: IRAK3
• Gene Alias: 4833428C18Rik; AI563835; ASRT5; FLJ13601; IL-1 receptor-associated kinase M; interleukin 1 receptor associated kinase 3; interleukin-1 receptor-associated kinase 3; IRAK3; IRAK-3; IRAKM; IRAK-M
• Host Species: Rabbit
• Purification Method: Antigen affinity chromatography
• Regulatory Status: RUO
• Gene ID (Entrez): 11213
• Content And Storage: Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
• Form: Liquid

• Applications: Western Blot, Immunocytochemistry
• Concentration: 0.22 mg/mL
• Formulation: 0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
• Gene Accession No.: Q9Y616
• Gene Symbols: IRAK3
• Immunogen: Recombinant fragment corresponding to a region within amino acids 58 and 357 of IRAK3 (Uniprot ID#Q9Y616).
• Quantity: 100 μL
• Primary or Secondary: Primary
• Target Species: Human
• Product Type: Antibody
• Isotype: IgG

Safety and Handling

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