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Invitrogen™ IRAK1BP1 Polyclonal Antibody
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Catalog No. PA550231
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100 μL
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PA550231 100 μL
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Catalog No. PA550231 Supplier Invitrogen™ Supplier No. PA550231
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Description

Rabbit Polyclonal Antibody

The antibody detects endogenous levels of total IRAK1BP1 protein.

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
TRUSTED_SUSTAINABILITY

Specifications

Antigen IRAK1BP1
Applications Immunohistochemistry (Paraffin), Western Blot
Classification Polyclonal
Concentration 0.3 mg/mL
Conjugate Unconjugated
Formulation PBS with 40% glycerol and 0.05% sodium azide; pH 7.4
Gene IRAK1BP1
Gene Accession No. Q5VVH5, Q9ESJ7
Gene Alias 4921528N06Rik; Aabp3; ActA binding protein 3; Acta-binding protein 70; AI851240; Aip70; interleukin 1 receptor associated kinase 1 binding protein 1; interleukin-1 receptor-associated kinase 1 binding protein 1; interleukin-1 receptor-associated kinase 1-binding protein 1; IRAK1-binding protein 1; Irak1bp1; MGC138458; MGC138460; PLK-interacting protein; signaling molecule that associates with the mouse pelle-like kinase; Simpl
Gene Symbols IRAK1BP1
Host Species Rabbit
Immunogen Full length fusion protein of Human IRAK1BP1.
Purification Method Antigen affinity chromatography
Quantity 100 μL
Regulatory Status RUO
Primary or Secondary Primary
Gene ID (Entrez) 134728, 65099
Target Species Human, Mouse
Content And Storage -20°C
Product Type Antibody
Form Liquid
Isotype IgG
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