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IRAK1BP1 Rabbit anti-Human, Mouse, Polyclonal, Invitrogen™

Rabbit Polyclonal Antibody

Manufacturer:  Invitrogen PA550231

Catalog No. PA550231


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Description

Description

The antibody detects endogenous levels of total IRAK1BP1 protein.

SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.
Specifications

Specifications

IRAK1BP1
Polyclonal
Unconjugated
IRAK1BP1
Liquid
IRAK1BP1
Full length fusion protein of Human IRAK1BP1
Antigen affinity chromatography
RUO
Antibody
Polyclonal
Human, Mouse
Immunohistochemistry (Paraffin), Western Blot
1.9 mg/mL
PBS with 50% glycerol and 0.05% sodium azide; pH 7.3
Q5VVH5, Q9ESJ7
AIP70, SIMPL
Rabbit
IgG
100 μL
-20°C
Primary
134728, 65099
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